Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tert-Butylamine → N-t-Butyl-4-chloro-2-fluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tert-Butylamine | HCID 6385 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 4-Chloro-2-fluorobenzoic acid | HCID 99152 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-t-Butyl-4-chloro-2-fluorobenzamide | HCID 10130797 | 96% |
반응 단계
To a suspension of 4-chloro-2-fluorobenzoic acid (0.3494 g, 2.00 mmol) in methylene chloride (10 ml) were added t-butylamine (0.32 ml, 3.05 mmol) and HOBt (0.3248 g, 2.40 mmol), and then WSC HCl (0.4596 g, 2.40 mmol) was added and stirred for 3 hours. The reaction mixture was added into water and extracted three times with ethyl acetate. The combined extracts were dried over MgSO4. The solvent was evaporated and the residue was purified by silica gel chromatography (hexane/ethyl acetate=5/1) to give the title compound (0.4403 g; 96%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06936736B2 |
| 출처 데이터셋 | uspto-grants-2005_08 |
| ORD ID | ord-15e4102d01554bf98427b75ddeba1303 |
| 출처 메모 | uspto-grants-2005_08 |