HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 587Generated: October 26, 2026
2-Methyl-2H-pyrazol-3-ylamine → (1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl](2-methylpropyl)amino}-3-methoxypyridin-2-yl)carbonyl]cyclopropanecarboxylic acid
https://huagongshe.com/reaction/587
Participants
| Role | Name | HCID | Charge |
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| Reactant | 2-Methyl-2H-pyrazol-3-ylamine | HCID 136927 | — |
| Reactant | (6S)-2-(2-chloro-5-methylpyrimidin-4-yl)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-8-one | HCID 129116843 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | Binap, (A+-)- | HCID 634876 | — |
| Catalyst | Palladium (II) acetate | HCID 4144353 | — |
| Product | (1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl](2-methylpropyl)amino}-3-methoxypyridin-2-yl)carbonyl]cyclopropanecarboxylic acid | HCID 122670103 | 15.7% |
Reaction Steps
18-mar-2014 17:15:52 +0100, blandar allt, add toluen, N2 flushar - rör 110 gC/ön/N2. Nästa em kl 16, fått svalna - LCMS ser bra ut, 17:49:27 - nu hydrolys/rt, klart efter 90 min ca, slår på 600 uL HoAc, evap. Till SSL, 24-mar-2014 190 mg åter från SSL. ( 1 g CBA prekond MeOH, löser i några ml ACN, eluerar mha 2.5 överkolonn vol, späder med avjonat aq, lyoph ön) HNMR OK LCMS OK
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
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| ORD ID | ord-81f0402c864a4618afac454715899838 |
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| Source note | 750 AstraZeneca ELN dataset |
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