HCID 22329075, compound → HCID 22329086, compound

HRID 587046Notes

Reaction equation

HRID 587046 reaction equation
C(OC([N:11]([CH2:22][CH2:23][O:24][CH2:25][CH3:26])[CH2:12][CH2:13][CH2:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=O)C1C=CC=CC=1>CO.[Pd]>[CH2:25]([O:24][CH2:23][CH2:22][NH:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][C:18]([CH3:19])([CH3:21])[CH3:20])=[O:16])[CH3:26]

Participants

4

Reactant 1

HCID 22329075HCID 22329075, compound

Product 1

HCID 22329086HCID 22329086, compoundYield 99.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In methanol (87 ml) was dissolved tert-butyl 4-[(benzyloxycarbonyl)(2-ethoxyethyl)amino]butyrate (8.7 g). To the solution was added 10% palladium/carbon (0.87 g), and the mixture was stirred for 3 hours under hydrogen atmosphere. 10% palladium/carbon was removed by filtration with Celite, and the solvent of the resulting solution was removed under reduced pressure to give tert-butyl 4-[(2-ethoxyethyl)amino]butyrate (5.5 g).

Workup

  1. custom10% palladium/carbon was removed by filtration with Celite
  2. customthe solvent of the resulting solution was removed under reduced pressure

Sources & evidence

ORD record
ord-adbd25eca96e4ba1a0d623371a0dfbe5
Source dataset
uspto-grants-2005_08
Patent number
US06936602B1

Reaction notes

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