Sodium Bicarbonate → HCID 22329277, compound

Participants

Reaction Steps

In ethyl acetate (22 ml) was dissolved tert-butyl 7-bromo-1-(2-ethoxyethyl)-2,3-dihydro-1-benzazepine-4-carboxylate (1.1 g). To the solution was added 4N hydrochloric acid/ethyl acetate (11 ml) at room temperature, and the mixture was stirred for 24 hours. An aqueous saturated solution of sodium hydrogen carbonate was added to adjust pH to approximate 4, followed by extraction with ethyl acetate. The extract was washed with saturated brine and dried with magnesium sulfate. The solvent was removed under reduced pressure, and the resulting residue was washed with hexane/ethyl acetate (=8/1) to give 7-bromo-1-(2-ethoxyethyl)-2,3-dihydro-1-benzazepine-4-carboxylic acid (0.73 g).

Provenance & Evidence