Hydrochloric Acid → HCID 22328982, compound

Participants

Reaction Steps

In THF (6.4 ml)/methanol (3.2 ml) was dissolved methyl 7-[4-(2-butoxyethoxy)phenyl]-1-(1-methyltetrazol-5-ylmethyl)-2,3-dihydro-1-benzazepine-4-carboxylate (0.32 g). To the solution was added 1N sodium hydroxide solution (3.2 ml), and the mixture was stirred at room temperature for 14 hours. pH was adjusted to approximate 4 with 1N hydrochloric acid, and the solvent was concentrated to half under reduced pressure. The concentrated material was extracted with ethyl acetate/THF, and the extract was washed with saturated brine and dried with magnesium sulfate. The solvent was removed under reduced pressure, and the resulting residue was washed with hexane/ethyl acetate (5/1) to give 7-[4-(2-butoxyethoxy)phenyl]-1-(1-methyltetrazol-5-ylmethyl)-2,3-dihydro-1-benzazepine-4-carboxylic acid (0.25 g).

Provenance & Evidence