Dimethylformamide → HCID 69521870, compound

Participants

Reaction Steps

To a solution of 7-[4-(2-butoxyethoxy)phenyl]-1-[(2-methyl-1,3-dioxolan-2-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid (300 mg) in THF (10 ml) were added thionyl chloride (0.068 ml) and DMF (one droplet) at room temperature, and the mixture was stirred for 1 hour. The reaction mixture was added dropwise to a solution of 4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]aniline (151 mg) and triethylamine (0.7 ml) in THF (3 ml) at 0° C. The mixture was stirred at room temperature for 20 hours, water was added thereto, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried with magnesium sulfate. After concentration under reduced pressure, the residue was separated and purified with column chromatography (ethanol:ethyl acetate=1:19→1:10), and the resulting crystals were purified by recrystallization (ethyl acetate-diisopropyl ether) to give 7-[4-(2-butoxyethoxy)phenyl]-1-[(2-methyl-1,3-dioxolan-2-yl)methyl]-N-[4-[[N-methyl-N-tetrahydropyran-4-yl)amino]methyl]phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxamide (Compound 107) (144 mg) as yellow crystals.

Provenance & Evidence