Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide | HCID 86679822 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 60197104 | HCID 60197104 | — |
Reaction Steps
To a solution of triazine A1 (300 mg, 1.0 mmol) in a mixture of THF (4 mL) and iPrOH (4 mL) were added morpholine (87 mg, 1.0 mmol) and DIPEA (200 μL, 1.15 mmol). The mixture was heated for 2 hours at 60° C. and the solvent removed under reduced pressure. The residue was treated with MeOH and the solid title compound (B10) collected by filtration, washed with MeOH, and dried in vacuo. Yield: 93.3 mg (27%), colorless amorphous solid. MS (ES) C14H18N6O3S requires: 350. found: 351 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09226929B2 |
|---|
| Source dataset | uspto-grants-2016_01 |
|---|
| ORD ID | ord-b4f11277db614da5836265594a9815c6 |
|---|
| Source note | uspto-grants-2016_01 |
|---|
