(Piperazin-2-yl)methanol → rac-3-[(4-(2-(Hydroxymethyl)piperazin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

HRID 587148Notes

Reaction equation

HRID 587148 reaction equation
N1(C2N=CN=C(NC3C=C(CS(N)(=O)=O)C=CC=3)N=2)CCCCC1.Cl[C:26]1[N:31]=[CH:30][N:29]=[C:28]([NH:32][C:33]2[CH:34]=[C:35]([CH2:39][S:40]([NH2:43])(=[O:42])=[O:41])[CH:36]=[CH:37][CH:38]=2)[N:27]=1.[OH:44][CH2:45][CH:46]1[CH2:51][NH:50][CH2:49][CH2:48][NH:47]1>>[OH:44][CH2:45][CH:46]1[CH2:51][NH:50][CH2:49][CH2:48][N:47]1[C:26]1[N:31]=[CH:30][N:29]=[C:28]([NH:32][C:33]2[CH:34]=[C:35]([CH2:39][S:40]([NH2:43])(=[O:42])=[O:41])[CH:36]=[CH:37][CH:38]=2)[N:27]=1

Participants

4

Reactant 3

HCID 11788288(Piperazin-2-yl)methanolHCID 601971013-[(4-(Piperidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethane sulfonamideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197201rac-3-[(4-(2-(Hydroxymethyl)piperazin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Procedure

B13 was prepared following the procedure reported for B1 using A1 and rac-2-(hydroxymethyl)piperazine. MS (ES) C15H21N7O3S requires: 379. found: 380 (M+H)+.

Workup

  1. customB13 was prepared

Sources & evidence

ORD record
ord-3e2e7ef0c7134ccfba4a21ef0af0a8ef
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

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