(S)-(+)-2-(Methoxymethyl)pyrrolidine → (S)-3-[(4-(2-(Methoxymethyl)pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

HRID 587153Notes

Reaction equation

HRID 587153 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:15]=[C:16]([CH2:20][S:21]([NH2:24])(=[O:23])=[O:22])[CH:17]=[CH:18][CH:19]=3)[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.ClC1N=CN=C(NC2C=C(CS(N)(=O)=O)C=CC=2)N=1.[CH3:44][O:45]C[C@@H]1CCCN1>>[CH3:44][O:45][CH2:6][C@@H:5]1[CH2:4][CH2:3][CH2:2][N:1]1[C:7]1[N:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]2[CH:15]=[C:16]([CH2:20][S:21]([NH2:24])(=[O:23])=[O:22])[CH:17]=[CH:18][CH:19]=2)[N:8]=1

Participants

4

Reactant 3

HCID 671217(S)-(+)-2-(Methoxymethyl)pyrrolidineHCID 601971013-[(4-(Piperidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethane sulfonamideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197305(S)-3-[(4-(2-(Methoxymethyl)pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Procedure

B18 was prepared following the procedure reported for B1 using A1 and (S)-2-(methoxymethyl)pyrrolidine. MS (ES) C16H22N6O3S requires: 378. found: 379 (M+H)+.

Workup

  1. customB18 was prepared

Sources & evidence

ORD record
ord-b445a354e4d54b1988132b9e082dda86
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

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