Methyl D-prolinate hydrochloride → (R)-Methyl 1-[4-((3-(Sulfamoylmethyl)phenyl)amino)-1,3,5-triazin-2-yl]pyrrolidine-2-carboxylate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Methyl D-prolinate hydrochloride	HCID 44629857	—
Edukt	rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide	HCID 60197106	—
Edukt	3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide	HCID 86679822	—
Produkt	(R)-Methyl 1-[4-((3-(Sulfamoylmethyl)phenyl)amino)-1,3,5-triazin-2-yl]pyrrolidine-2-carboxylate	HCID 60197308	—

Reaktionsschritte

B21 was obtained as a white crystalline solid by following the procedure reported for B4 using A1 and (R)-proline methyl ester hydrochloride; yield: 158 mg (45%). 1H NMR (300 MHz, d6-DMSO, 300K) δ 1.88-2.08 (m, 3H), 2.22-2.42 (m, 1H), 3.50-3.77 (m, 2H), 3.55 and 3.60 (2 s, 3H), 4.22 (2 s, 2H), 4.50-4.67 (m, 1H), 6.88 (bs, 2H), 6.97-7.05 (m, 1H), 7.20-7.32 (m, 1H), 7.60-7.72 (m, 1H), 7.68 and 7.89 (2bs, 1H), 8.19 and 8.26 (2 s, 1H), 9.73 and 9.78 (2 s, 1H). MS (ES) C16H20N6O4S requires: 392. found: 393 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09226929B2
Quelldatensatz	uspto-grants-2016_01
ORD ID	ord-857639f1a6184e3fa22044fc6bcaf277
Quellennotiz	uspto-grants-2016_01