HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl L-prolinate hydrochloride → (S)-Methyl 1-[4-((3-(Sulfamoylmethyl)phenyl)amino)-1,3,5-triazin-2-yl]pyrrolidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl L-prolinate hydrochloride | HCID 2733200 | — |
| Reactant | rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide | HCID 60197106 | — |
| Reactant | 3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide | HCID 86679822 | — |
| Product | (S)-Methyl 1-[4-((3-(Sulfamoylmethyl)phenyl)amino)-1,3,5-triazin-2-yl]pyrrolidine-2-carboxylate | HCID 60197403 | — |
Reaction Steps
B22 was obtained as a white crystalline solid by following the procedure reported for B4 using A1 and (S)-proline methyl ester hydrochloride; yield: 169 mg (48%). MS (ES) C16H20N6O4S requires: 392. found: 393 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09226929B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-cc61011c7d6d4a35a57626b77d338e79 |
| Source note | uspto-grants-2016_01 |