(R)-(-)-2-(Anilinomethyl)pyrrolidine → HCID 60197501, compound

HRID 587162Notes

Reaction equation

HRID 587162 reaction equation
COCC1CCCCN1C1N=CN=C(NC2C=C(CS(N)(=O)=O)C=CC=2)N=1.Cl[C:29]1[N:34]=[CH:33][N:32]=[C:31]([NH:35][C:36]2[CH:37]=[C:38]([CH2:42][S:43]([NH2:46])(=[O:45])=[O:44])[CH:39]=[CH:40][CH:41]=2)[N:30]=1.[C:47]1([NH:53][CH2:54][C@H:55]2[CH2:59][CH2:58][CH2:57][NH:56]2)[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1>>[C:47]1([NH:53][CH2:54][C@H:55]2[CH2:59][CH2:58][CH2:57][N:56]2[C:29]2[N:34]=[CH:33][N:32]=[C:31]([NH:35][C:36]3[CH:37]=[C:38]([CH2:42][S:43]([NH2:46])(=[O:45])=[O:44])[CH:39]=[CH:40][CH:41]=3)[N:30]=2)[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=1

Participants

4

Reactant 3

HCID 6950383(R)-(-)-2-(Anilinomethyl)pyrrolidineHCID 60197106rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197501HCID 60197501, compound

Procedure

B29 was prepared following the procedure reported for B4 using A1 and (R)-2-(phenylamino-methyl)pyrrolidine. It was obtained as a white crystalline solid; yield: 245 mg (62%). MS (ES) C21H25N7O2S requires: 439. found: 440 (M+H)+.

Workup

  1. customB29 was prepared
  2. customIt was obtained as a white crystalline solid

Sources & evidence

ORD record
ord-3215974729bb40739efc53d8843c552f
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

Loading…