rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide → HCID 60197599, compound

HRID 587168Notes

Reaction equation

HRID 587168 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[CH2:9]CC[CH2:6][N:5]1[C:10]1[N:15]=[CH:14][N:13]=[C:12]([NH:16][C:17]2[CH:18]=[C:19]([CH2:23][S:24]([NH2:27])(=[O:26])=[O:25])[CH:20]=[CH:21][CH:22]=2)[N:11]=1.ClC1N=CN=C(NC2C=C(CS(N)(=O)=[O:44])C=CC=2)N=1.Cl.N1CC[C@@H]1C(OC)=O>>[S:24]([CH2:23][C:19]1[CH:18]=[C:17]([NH:16][C:12]2[N:13]=[CH:14][N:15]=[C:10]([N:5]3[CH2:6][CH2:9][C@@H:4]3[C:3]([O:2][CH3:1])=[O:44])[N:11]=2)[CH:22]=[CH:21][CH:20]=1)(=[O:26])(=[O:25])[NH2:27]

Participants

4

Reactant 3

HCID 60197106rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamideHCID 68683921Methyl (2R)-azetidine-2-carboxylate--hydrogen chloride (1/1)HCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197599HCID 60197599, compound

Procedure

B36 was prepared following the general procedure reported for B4 using A1 and A7 and obtained as white crystals; yield: 60 mg (18%). MS (ES) C15H18N16O4S requires: 378. found: 379 (M+H)+.

Workup

  1. customB36 was prepared
  2. customobtained as white crystals

Sources & evidence

ORD record
ord-68070b0989f14e92b2ace10e73cc613e
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

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