1,2,3,4-Tetrahydroisoquinoline → HCID 60197603, compound

HRID 587172Notes

Reaction equation

HRID 587172 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)[N:3]=1.[CH2:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][NH:21]1>>[CH2:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][N:21]1[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)[N:3]=1

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197603HCID 60197603, compound

Procedure

B40 was prepared following the general procedure reported for B10 using A1 and 1,2,3,4-tetrahydroisoquinoline; yield: 23.6 mg (6%), colorless amorphous solid. MS (ES) C19H20N6O2S requires: 396. found: 397 (M+H)+.

Workup

  1. customB40 was prepared

Sources & evidence

ORD record
ord-5277f88441c740dca69396dbf97d0261
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

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