4,5,6,7-Tetrahydrothieno(3,2-c)pyridine → 3-[(4-(6,7-Dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

HRID 587175Notes

Reaction equation

HRID 587175 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)[N:3]=1.[S:20]1[C:28]2[CH2:27][CH2:26][NH:25][CH2:24][C:23]=2[CH:22]=[CH:21]1>>[S:20]1[C:28]2[CH2:27][CH2:26][N:25]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=4)[N:3]=3)[CH2:24][C:23]=2[CH:22]=[CH:21]1

Participants

3

Reactant 2

HCID 30850764,5,6,7-Tetrahydrothieno(3,2-c)pyridineHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 601977023-[(4-(6,7-Dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Procedure

B43 was prepared following the general procedure reported for B10 using A1 and 4,5,6,7-tetrahydrothieno[3,2-c]pyridine; yield: 88.6 mg (22%), white amorphous solid. MS (ES) C17H18N6O2S2 requires: 402. found: 403 (M+H)+.

Workup

  1. customB43 was prepared

Sources & evidence

ORD record
ord-430e045d3ac94577b9bb243b2eaa24cc
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

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