5,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine → 3-[(4-(5,6-Dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

HRID 587178Notes

Reaction equation

HRID 587178 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:15]=[C:16]([CH2:20][S:21]([NH2:24])(=[O:23])=[O:22])[CH:17]=[CH:18][CH:19]=3)[N:8]=2)[CH2:6][CH2:5]CC[CH2:2]1.[N:25]1[CH:26]=CN2CC[NH:31][CH2:30][C:29]=12>>[N:31]1[CH:30]=[CH:29][N:25]2[CH2:26][CH2:2][N:1]([C:7]3[N:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]4[CH:15]=[C:16]([CH2:20][S:21]([NH2:24])(=[O:23])=[O:22])[CH:17]=[CH:18][CH:19]=4)[N:8]=3)[CH2:6][C:5]=12

Participants

3

Reactant 2

HCID 132470465,6,7,8-Tetrahydroimidazo(1,2-a)pyrazineHCID 601971013-[(4-(Piperidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethane sulfonamide

Product 1

HCID 601977053-[(4-(5,6-Dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Procedure

B46 was prepared following the procedure reported for B1 using Al and 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine. MS (ES) C16H18N8O2S requires: 386. found: 387 (M+H)+.

Workup

  1. customB46 was prepared

Sources & evidence

ORD record
ord-a1b66d6048424a0084511eb45f4679b6
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

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