2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine--hydrogen chloride (1/1) → HCID 60197809, compound

HRID 587181Notes

Reaction equation

HRID 587181 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)[N:3]=1.Cl.[CH2:21]1[C:29]2[CH:28]=[CH:27][N:26]=[CH:25][C:24]=2[CH2:23][NH:22]1>>[CH2:21]1[C:29]2[CH:28]=[CH:27][N:26]=[CH:25][C:24]=2[CH2:23][N:22]1[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)[N:3]=1

Participants

3

Reactant 2

HCID 189536452,3-Dihydro-1H-pyrrolo[3,4-c]pyridine--hydrogen chloride (1/1)HCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197809HCID 60197809, compound

Procedure

B49 was prepared following the general procedure reported for B10 using A1 and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine hydrochloride; yield: 139.0 mg (36%), brown amorphous solid. 1H NMR (400 MHz, d6-DMSO, 300K) δ 4.27 (s, 2H), 4.92 (s, 2H), 4.97 and 4.99 (2 s, 2H), 6.87 and 6.88 (2 s, 2H), 7.01 (d, J=7.5 Hz, 1H), 7.30 (t, J=7.9 Hz, 1H), 7.59-7.72 (m, 2H), 7.98 (bs, 1H), 8.31 (d, J=1.4 Hz, 1H), 8.62 (t, J=6.0 Hz, 1H), 8.76 (d, J=5.7 Hz, 1H), 9.82 (s, 1H). MS (ES) C17H17N7O2S requires: 383. found: 384 (M+H)+.

Workup

  1. customB49 was prepared

Sources & evidence

ORD record
ord-72aaf132e6d14aa6afd5ba9518225fcd
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

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