1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole--hydrogen chloride (1/2) → HCID 60197811, compound

HRID 587183Notes

Reaction equation

HRID 587183 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)[N:3]=1.Cl.Cl.[NH:22]1[C:26]2[CH2:27][NH:28][CH2:29][C:25]=2[CH:24]=[N:23]1>>[NH:22]1[C:26]2[CH2:27][N:28]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:10]=[C:11]([CH2:15][S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=4)[N:3]=3)[CH2:29][C:25]=2[CH:24]=[N:23]1

Participants

3

Reactant 2

HCID 468400121,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole--hydrogen chloride (1/2)HCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197811HCID 60197811, compound

Procedure

B51 was prepared following the general procedure reported for B10 using A1 and 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole dihydrochloride; yield: 194.9 mg (52%), colorless amorphous solid. 1H NMR (400 MHz, d6-DMSO, 300K) δ 4.23 (s, 2H), 4.58 (s, 2H), 4.64 (s, 2H), 6.83 (s, 2H), 7.00 (d, J=7.7 Hz, 1H), 7.26-7.34 (m, 1H), 7.58 (s, 1H), 7.71-7.78 (m, 1H), 7.86 (s, 1H), 8.27 (s, 1H), 9.73 (s, 1H), 12.73 (s, 1H). MS (ES) C15H16N8O2S requires: 372. found: 373 (M+H)+.

Workup

  1. customB51 was prepared

Sources & evidence

ORD record
ord-a7fbe7cfbfdc4057850bc0e8e60e5493
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Reaction notes

Loading…