huagongshe.com
HRID587325

反应详情

EQUATION

反应方程式

HRID 587325 的结构方程式

REACTANTS

反应物

2
结构：CN(C(=O)Oc1ccc(F)cc1)[C@H]1CNC[C@@H]1c1ccc(Cl)c(Cl)c1
HCID67234230

未命名化合物

结构：O=C(O)[C@H]1CC[C@H](O)CC1
HCID178525780

未命名化合物

PRODUCTS

生成物

1
结构：CN(C(=O)Oc1ccc(F)cc1)[C@H]1CN(C(=O)[C@H]2CC[C@H](O)CC2)C[C@@H]1c1ccc(Cl)c(Cl)c1
HCID178485977

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for the synthesis of example 1 (step f), the title compound rac-[(3R,4S)-4-(3,4-Dichloro-phenyl)-1-(trans-4-hydroxy-cyclohexanecarbonyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester was prepared from rac-[(3R,4S)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester instead of rac-[(3R,4S)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid tert-butyl ester using trans-4-hydroxycyclohexanecarboxylic acid instead of 1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carboxylic acid and was obtained as a light brown oil. MS m/e: 509.3 [M]+.

WORKUP

后处理

  1. customIn analogy to the procedure described for the synthesis of example 1 (step f)
  2. customwas obtained as a light brown oil