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HRID587332

反应详情

EQUATION

反应方程式

HRID 587332 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)N1CCC(C(=O)O)CC1
HCID117255

1-Acetylpiperidine-4-carboxylic acid

C8H13NO3

结构：CN(C(=O)Oc1ccc(F)cc1)[C@H]1CNC[C@@H]1c1ccc(Cl)c(Cl)c1
HCID67234230

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(Cl)c(Cl)c3)[C@@H](N(C)C(=O)Oc3ccc(F)cc3)C2)CC1
HCID58302993

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for the synthesis of example 44 (step c), the title compound rac-[(3R,4S)-1-(1-acetyl-piperidine-4-carbonyl)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester was prepared from rac-[(3R,4S)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester using 1-acetylpiperidine-4-carboxylic acid instead of 1-methylcyclopropane-1-carboxylic acid and was obtained as a brown oil. MS m/e: 536.1 [M]+.

WORKUP

后处理

  1. customIn analogy to the procedure described for the synthesis of example 44 (step c)
  2. customwas obtained as a brown oil