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HRID587335

反应详情

EQUATION

反应方程式

HRID 587335 的结构方程式

REACTANTS

反应物

2
结构：COCC(=O)Cl
HCID96623

Acetyl chloride, methoxy-

C3H5ClO2

结构：CN(C(=O)Oc1ccc(F)cc1)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccc(Cl)c(Cl)c1
HCID58303080

未命名化合物

PRODUCTS

生成物

1
结构：COCC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(Cl)c(Cl)c3)[C@@H](N(C)C(=O)Oc3ccc(F)cc3)C2)CC1
HCID58303166

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for the synthesis of example 73, the title compound rac-{(3R,4S)-4-(3,4-dichloro-phenyl)-1-[1-(2-methoxy-acetyl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-methyl-carbamic acid 4-fluoro-phenyl ester was prepared from rac-[(3R,4S)-4-(3,4-dichloro-phenyl)-1-(piperidine-4-carbonyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester using methoxyacetyl chloride instead of propionyl chloride and was obtained as a white foam. MS m/e: 566.3 [M]+.

WORKUP

后处理

  1. customIn analogy to the procedure described for the synthesis of example 73
  2. customwas obtained as a white foam