反应详情

In analogy to the procedure described for the synthesis of example 44 (step c), the title compound rac-[(3R,4S)-1-[1-(6-Chloro-pyridazin-3-yl)-piperidine-4-carbonyl]-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester was prepared from rac-[(3R,4S)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester using 1-(6-chloro-3-pyridazinyl)-4-piperidinecarboxylic acid instead of 1-methylcyclopropane-1-carboxylic acid and was obtained as an off-white foam. MS m/e: 608.1 [M+H]+.

1. customIn analogy to the procedure described for the synthesis of example 44 (step c)
2. customwas obtained as an off-white foam