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HRID587348

反应详情

EQUATION

反应方程式

HRID 587348 的结构方程式

REACTANTS

反应物

2
结构：CN(C(=O)Oc1ccc(F)cc1)[C@@H]1CNC[C@H]1c1ccc(Cl)cc1
HCID67233751

未命名化合物

结构：O=C(O)[C@H]1CC[C@H](O)CC1
HCID178525780

未命名化合物

PRODUCTS

生成物

1
结构：CN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCC(O)CC2)C[C@H]1c1ccc(Cl)cc1
HCID53244605

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for the synthesis of example 44 (step c), the title compound [(3S,4R)-4-(4-Chloro-phenyl)-1-(4-hydroxy-cyclohexanecarbonyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester was prepared from [(3S,4R)-4-(4-chloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester instead of rac-[(3S,4R)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester using trans-4-hydroxycyclohexanecarboxylic acid instead of 1-methylcyclopropane-1-carboxylic acid and was obtained as an off-white foam. MS m/e: 475.2 [M+H]+.

WORKUP

后处理

  1. customIn analogy to the procedure described for the synthesis of example 44 (step c)
  2. customwas obtained as an off-white foam