反应详情

温度

60 °C

A mixture of 20 mg (0.043 mmol) [(3S,4R)-4-(4-Chloro-phenyl)-1-(piperidine-4-carbonyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester, 11.2 uL (0.065 mmol) DIPEA and 12.8 mg (0.054 mmol) 2-bromo-5-(methylsulfonyl)pyridine in 1 mL DMF was heated to 60° C. over night. The mixture was subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and NEt3 to yield after evaporation of the product containing fractions the title compound as light yellow viscous oil. MS m/e: 615.3 [M]+.

1. customThe mixture was subjected to purification by preparative HPLC on reversed phase
2. washeluting with a gradient
3. customformed from acetonitrile, water and NEt3
4. customto yield
5. customafter evaporation of the product
6. additioncontaining fractions the title compound as light yellow viscous oil