HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 58303201, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 16795673 | HCID 16795673 | — |
| Reactant | [(3S,4R)-4-(4-chloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester | HCID 67233751 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58303201 | HCID 58303201 | — |
Reaction Steps
A mixture of 26.7 mg (0.085 mmol)[(3S,4R)-4-(4-chloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester, 15 mg (0.068 mmol) 1-(5-methyl-2-pyridinyl)-4-piperidinecarboxylic acid (commercially available), 31 mg (0.082 mmol) HATU and 70 uL (0.409 mmol) DIPEA in 2 mL DMF was shaken for 1 h at room temperature. The mixture was subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and NEt3 to yield after evaporation of the product containing fractions the title compound as off-white solid. MS m/e: 551.4 [M]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09226916B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-e86ebd7f43ba4087b263a578a4d5b48b |
| Source note | uspto-grants-2016_01 |