反应详情

To a cold solution of 100 ml methanol is slowly added 100 ml thionyl chloride followed by 30 g of 5-chlorosalicylic acid. This is then refluxed overnight, the solvent removed and the residue dissolved in ether. The ether is washed with a sodium bicarbonate solution, water, dried over magnesium sulfate and evaporated to dryness to obtain methyl 5-chlorosalicylate which is used directly in the next step.

1. temperatureThis is then refluxed overnight
2. customthe solvent removed
3. dissolutionthe residue dissolved in ether
4. washThe ether is washed with a sodium bicarbonate solution, water
5. dry with materialdried over magnesium sulfate
6. customevaporated to dryness