Acetic Acid → Methyl 4-acetamido-5-chloro-2-methoxybenzoate

HRID 5878ノート

反応式

HRID 5878 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([NH2:13])[C:10]([Cl:14])=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[C:15](O)(=[O:17])[CH3:16]>C(OC(=O)C)(=O)C>[CH3:1][O:2][C:3]1[CH:12]=[C:11]([NH:13][C:15](=[O:17])[CH3:16])[C:10]([Cl:14])=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 700493Methyl 4-amino-5-chloro-2-methoxybenzoate

生成物 1

HCID 77721Methyl 4-acetamido-5-chloro-2-methoxybenzoate

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

A mixture of 21 g of methyl 2-methoxy-4-amino-5-chlorobenzoate is stirred in 12 ml acetic anhydride and 100 ml acetic acid at 100° C. for 24 hours. The reaction mixture is filtered, diluted with water, filtered and evaporated to dryness to obtain methyl 2-methoxy-4-acetylamino-5-chlorobenzoate which is used directly in the next step.

後処理

  1. filtrationThe reaction mixture is filtered
  2. additiondiluted with water
  3. filtrationfiltered
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-43ac3093e75347328275d77d7718f91d
出典データセット
uspto-grants-1993_09
特許番号
US05246942

反応ノート

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