Methanol → 2-Cyano-5-formyl bicyclo[2.2.1]heptane
Reaction equation
[C:1]([CH:3]1[CH2:8][CH:7]2[CH2:9][CH:4]1[CH:5](C=O)[CH2:6]2)#[N:2].[CH3:12][OH:13]>[Co]>[C:1]([CH:3]1[CH2:8][CH:7]2[CH2:9][CH:4]1[CH2:5][CH:6]2[CH:12]=[O:13])#[N:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
89.5 g (0.6 mol) of 2-Cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane which had been obtained in Example 1, methanol (89.5 g) and 4.5 g (as dried mass) of Raney cobalt catalyst (cobalt 94 mass %, aluminum 3.5 mass %, manganese 2.1 mass %) obtained by developing a cobalt-aluminum alloy containing manganese were added in a stainless steel autoclave of electromagnetic stirring having an inner volume of 0.5 liter, and ammonia gas (24.5 g, 1.44 mol) was blown in the autoclave.
Sources & evidence
- ORD record
- ord-403b27312c93474582884813840d395f
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09227925B2
Reaction notes
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