HCID 11667292, compound → HCID 14018969, compound

HRID 587941Notes

Reaction equation

HRID 587941 reaction equation
C([O:8][C:9]1[CH:25]=[CH:24][C:12]([CH2:13][CH2:14][N:15]([CH3:23])[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][CH2:14][N:15]([CH3:23])[C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:21])[CH3:19])=[CH:24][CH:25]=1

Participants

4

Reactant 1

HCID 11667292HCID 11667292, compound

Product 1

HCID 14018969HCID 14018969, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1.13 g (3.32 mmol) of tert-butyl 4-(benzyloxy)phenethyl(methyl)carbamate in 15 mL of methanol was added 35 mg of 10% palladium on carbon. The reaction was stirred under a hydrogen balloon atmosphere for 6 h, filtered through celite and evaporated to give tert-butyl 4-hydroxyphenethyl(methyl)carbamate as a colorless oil which was subsequently used without purification.

Workup

  1. filtrationfiltered through celite
  2. customevaporated

Sources & evidence

ORD record
ord-fd446867fb964e2ba8c7a5bc92fb991a
Source dataset
uspto-grants-2016_01
Patent number
US09227918B2

Reaction notes

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