5-Bromo-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile → HCID 25130663, compound

HRID 587958Notes

Reaction equation

HRID 587958 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[C:6]#[N:7].[CH3:21][NH:22][CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH:34]=[CH:35][CH:36]=1)[C:28]([O:30][CH2:31][CH2:32][CH3:33])=[O:29]>>[C:6]([C:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:3][CH2:2][N:22]([CH3:21])[CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH:34]=[CH:35][CH:36]=1)[C:28]([O:30][CH2:31][CH2:32][CH3:33])=[O:29])#[N:7]

Participants

3

Reactant 2

HCID 135355715-Bromo-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrileHCID 59419920HCID 59419920, compound

Product 1

HCID 25130663HCID 25130663, compound

Procedure

Reaction of 1f with 2g produced 3af. MS found M+H=481. The oxalate salt of 3af was recrystallized from ethyl acetate; mp 110-114° C.

Workup

  1. customproduced 3af
  2. customThe oxalate salt of 3af was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-3c272c897a9640c8be4312df5ad927e2
Source dataset
uspto-grants-2016_01
Patent number
US09227918B2

Reaction notes

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