5-Bromo-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile → HCID 25130664, compound

HRID 587959Notes

Reaction equation

HRID 587959 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[C:6]#[N:7].[CH3:21][O:22][C:23]1[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][NH:35][CH3:36])=[CH:29][C:24]=1[C:25]([O:27][CH3:28])=[O:26]>>[C:6]([C:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:3][CH2:2][N:35]([CH3:36])[CH2:34][CH2:33][C:30]1[CH:31]=[CH:32][C:23]([O:22][CH3:21])=[C:24]([CH:29]=1)[C:25]([O:27][CH3:28])=[O:26])#[N:7]

Participants

3

Reactant 2

HCID 135355715-Bromo-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrileHCID 59419928HCID 59419928, compound

Product 1

HCID 25130664HCID 25130664, compound

Procedure

Reaction of 1f with 2h produced 3ag. MS found M+H=483. The oxalate salt of 3ag was recrystallized from ethyl acetate; mp 76-81° C.

Workup

  1. customproduced 3ag
  2. customThe oxalate salt of 3ag was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-eb02d563e18942e49028ff1b50d9dfaa
Source dataset
uspto-grants-2016_01
Patent number
US09227918B2

Reaction notes

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