5-Bromo-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile → HCID 25131313, compound

HRID 587967Notes

Reaction equation

HRID 587967 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[C:6]#[N:7].[CH3:21][NH:22][CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH:35]=[CH:36][CH:37]=1)[C:28]([O:30][CH2:31][CH2:32][CH2:33][CH3:34])=[O:29]>>[C:6]([C:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:3][CH2:2][N:22]([CH3:21])[CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH:35]=[CH:36][CH:37]=1)[C:28]([O:30][CH2:31][CH2:32][CH2:33][CH3:34])=[O:29])#[N:7]

Participants

3

Reactant 2

HCID 135355715-Bromo-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrileHCID 59419937HCID 59419937, compound

Product 1

HCID 25131313HCID 25131313, compound

Procedure

Reaction of 1f with 2m produced 3ar. MS found M+H=495. The oxalate salt of 3ar was recrystallized from methanol/ether; mp 97-103° C.

Workup

  1. customproduced 3ar
  2. customThe oxalate salt of 3ar was recrystallized from methanol/ether

Sources & evidence

ORD record
ord-fd72349b4ec2484ba324fce1ef0388cc
Source dataset
uspto-grants-2016_01
Patent number
US09227918B2

Reaction notes

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