5-Bromo-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile → HCID 25131315, compound

HRID 587969Notes

Reaction equation

HRID 587969 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[C:6]#[N:7].[CH3:21][NH:22][CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH2:31][C:32]([O:34][CH3:35])=[O:33])[CH:28]=[CH:29][CH:30]=1>>[C:6]([C:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:3][CH2:2][N:22]([CH3:21])[CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH2:31][C:32]([O:34][CH3:35])=[O:33])[CH:28]=[CH:29][CH:30]=1)#[N:7]

Participants

3

Reactant 2

HCID 135355715-Bromo-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrileHCID 59419933HCID 59419933, compound

Product 1

HCID 25131315HCID 25131315, compound

Procedure

Reaction of 1f with 2o produced 3at. MS found M+H=467. The oxalate salt of 3at was recrystallized from ethyl acetate; mp 77-82° C.

Workup

  1. customproduced 3at
  2. customThe oxalate salt of 3at was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-24ac5d5178014aae8651b496a739f4e4
Source dataset
uspto-grants-2016_01
Patent number
US09227918B2

Reaction notes

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