HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate → (S)-tert-butyl 3-formylpyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 1514341 | — |
| Reactant | Tempo | HCID 2724126 | — |
| Product | (S)-tert-butyl 3-formylpyrrolidine-1-carboxylate | HCID 1514343 | — |
Reaction Steps
The alcohol starting materials can be prepared by the 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical (TEMPO) mediated oxidation of (S)-3-hydroxymethylpyrrolidine-1-carboxylic acid t-butyl ester to yield (S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227933B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-1e97e069a2bd40478ba7859d69634d32 |
| Source note | uspto-grants-2016_01 |