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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 588061Generated: October 31, 2026

Methyl 6-aminonicotinate → HCID 71495430, compound

https://huagongshe.com/reaction/588061

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 6-aminonicotinateHCID 737487—
Reactant2-Aminomethyl-4-(4-fluorobenzyl)morpholineHCID 10242735—
ProductHCID 71495430HCID 7149543028.6%

Reaction Steps

The title compound was prepared in the same manner as in Example 32, with the exception that methyl 6-aminonicotinate, instead of 4-(4-fluorobenzyl)morpholin-2-ylmethylamine, was used in the same molar amount (Total yield: 28.6%). 1H NMR (CDCl3) δ 8.92 (s, 1H), 8.63 (s, 1H), 8.35 (s, 1H), 8.29 (d, 1H), 8.18 (d, 1H), 7.78 (d, 1H), 7.35 (m, 5H), 6.53 (m, 1H), 4.13 (m, 1H), 3.97 (s, 3H), 3.56 (s, 2H), 2.86 (d, 2H), 2.28 (t, 2H), 2.09 (d, 2H), 1.65 (m, 2H) ppm.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09227955B2
Source datasetuspto-grants-2016_01
ORD IDord-6a434f7fbbcb4801813057e2a6db2607
Source noteuspto-grants-2016_01