HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 588088Generated: October 31, 2026
N-bromobutanimide → 4-(bromomethyl)-6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine
https://huagongshe.com/reaction/588088
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 6-chloro-3-methoxy-4-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridine | HCID 118272149 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(bromomethyl)-6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine | HCID 118271789 | — |
Reaction Steps
6-Chloro-3-methoxy-4-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridine (1.5 g, 3.41 mmol) was dissolved in CCl4 (10 mL), charged with NBS (637 mg, 3.58 mmol) and AlBN (56.0 mg, 0.341 mmol), and heated to 70° C. overnight. The reaction was diluted with DCM (10 mL) and purified by flash chromatography (5-25% EtOAc/hexanes) to give 4-(bromomethyl)-6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine. MS ESI calc'd. for C27H21BrClN3O [M+1]+519. found 519.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09226922B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-df5050c4d9134430a27d1efe6361b819 |
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| Source note | uspto-grants-2016_01 |
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