Hydrochloric Acid → 3-Bromo-1-(triphenylmethyl)-1H-pyrazolo[4,3-c]pyridine-6-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a suspension of methyl 3-bromo-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carboxylate (6.0 g, 12.04 mmol) in MeOH (60 mL) was added KOH (1 N, 42.1 mL, 42.1 mmol). The reaction mixture was heated to 50° C. for 1 h. After cooling down to room temperature, 1 N HCl was added until the pH of the reaction mixture reached 4. The solid was collected by filtration and washed with H2O to afford 3-bromo-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carboxylic acid. MS ESI calc'd. for C26H19BrN3O2 [M+H]+ 484. found 484.

Provenance & Evidence