HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 588103Generated: October 29, 2026
Hydrazine hydrate (1:1) → 6-chloro-4-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridin-3(2H)-one
https://huagongshe.com/reaction/588103
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4,6-Dichloro-2-trifluoromethyl-nicotinic acid methyl ester | HCID 59678207 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-chloro-4-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridin-3(2H)-one | HCID 118272490 | — |
Reaction Steps
A solution of methyl 4,6-dichloro-2-(trifluoromethyl)nicotinate (535.9 mg, 1.956 mmol) in DMF (2 ml) was charged with hydrazine hydrate (190 μL, 3.92 mmol) and heated to 150° C. for 30 min under microwave irradiation. Concentrated in vacuo and washed residue with DCM. Purified via flash chromatography (0-20% MeOH/DCM) to provide 6-chloro-4-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridin-3(2H)-one MS: [M+H]+ m/z 238.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09226922B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-d21975efff9b45ca9a2145d53240a433 |
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| Source note | uspto-grants-2016_01 |
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