Potassium cyanate → HCID 118183915, compound

HRID 588118Notes

Reaction equation

HRID 588118 reaction equation
[NH2:1][C@@H:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:3]([OH:5])[CH3:4].[O-:12][C:13]#[N:14].[K+]>O>[OH:5][CH:3]([CH3:4])[C@@H:2]([NH:1][C:13]([NH2:14])=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 11378442Potassium cyanateHCID 118183913HCID 118183913, compound

Product 1

HCID 118183915HCID 118183915, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of (1S)-1-amino-1-phenylpropan-2-ol (0.43 g, 2 mmol) in H2O (2 mL) was added potassium cyanate (0.23 g, 2.7 mmol) and the contents were stirred at ambient temperature for 2 hr. The solid thus obtained was filtered and washed successively with H2O (2×5 mL) and dried in air to afford 1-((1S)-2-hydroxy-1-phenylpropyl)urea. MS: [M+H]+ m/z 195.

Workup

  1. customThe solid thus obtained
  2. filtrationwas filtered
  3. washwashed successively with H2O (2×5 mL)
  4. customdried in air

Sources & evidence

ORD record
ord-b0dfb4e865cf4610be978b9cee8d6e2b
Source dataset
uspto-grants-2016_01
Patent number
US09226922B2

Reaction notes

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