Ethanol → HCID 118183914, compound

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Reaction Steps

The enantiomers of 1-((1S)-2-hydroxy-1-phenylpropyl)urea (2.86 g, 14.72 mmol) were separated by SFC (Thar 80, Column: Phenomenex Lux-4 21×250 (mm), UV wavelength: 220 nM, mobile phase: 25:75 Ethanol+0.25% dimethyl ethyl amine in CO2(l), flow rate: 70 mL/min, Run Time: 7.1 min). The fractions were collected and the solvent evaporated in vacuo to afford 1-((1S,2R)-2-hydroxy-1-phenylpropyl)urea (Intermediate 23B). MS: [M+H]+ m/z 195.

Provenance & Evidence