Methanol → HCID 118272111, compound

Participants

Reaction Steps

The enantiomers of (R)-1-(2,2-dimethyl-1-phenylpropyl)urea (600 mg, 2.9 mmol) were separated by SFC (Berger Multigram II SFC, column: Chiral Technology AD-H 2.1×25 cm, 5 uM, mobile phase: 20% Methanol in CO2(l), flow rate: 70 mL/min) The fractions were collected and the solvent evaporated in vacuo to afford (R)-1-(2,2-dimethyl-1-phenylpropyl)urea (MS: [M+H]+ m/z 207) and (S)-1-(2,2-dimethyl-1-phenylpropyl)urea (MS: [M+H]+ m/z 207).

Provenance & Evidence