HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoethanol → 2-((6-chloro-4-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)oxy)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | 6-chloro-4-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridin-3(2H)-one | HCID 118272136 | — |
| Product | 2-((6-chloro-4-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)oxy)ethanol | HCID 118272338 | — |
Reaction Steps
In a manner similar to that previously described (e.g. Scheme 3/Step 1 and the synthesis of Intermediate 20B/Step 6), 6-chloro-4-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridin-3(2H)-one (4B) was reacted with 2-bromoethanol (K2CO3, DMF. 2-bromoethanol. RT, 18 h) to provide 2-((6-chloro-4-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)oxy)ethanol (66B). MS: [M+H]+ m/z 470.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09226922B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-0323d2f1d33b43bb8e0220d5b72637d0 |
| Source note | uspto-grants-2016_01 |