HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-1-(1-phenylethyl)urea → (R)-1-(4-Formyl-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-1-(1-phenylethyl)urea | HCID 13013340 | — |
| Reactant | 6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine-4-carbaldehyde | HCID 118271999 | — |
| Product | (R)-1-(4-Formyl-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea | HCID 118271861 | — |
Reaction Steps
In a manner similar to that described previously (e.g. Scheme 3/Method A and Example 40), 6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine-4-carbaldehyde (Intermediate 11B) was reacted with converted to (R)-1-(1-phenylethyl)urea (BrettPhos PreCatalyst, cesium carbonate, dioxane, 90° C. for 4 hrs) to provide (R)-1-(4-formyl-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea. MS: [M+H]+ m/z 582.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09226922B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-b1f2491f14464db5baf4a654abfafdb2 |
| Source note | uspto-grants-2016_01 |