HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl acrylate → 3-[2-(4-Hydroxy-phenyl)-morpholin-4-yl]-propionic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl acrylate | HCID 15458 | — |
| Reactant | 4-(Morpholin-2-yl)phenol | HCID 53804579 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-[2-(4-Hydroxy-phenyl)-morpholin-4-yl]-propionic acid tert-butyl ester | HCID 66654062 | 77.2% |
Reaction Steps
A mixture of 4-morpholin-2-yl-phenol (3.95 g; 22.0 mmol), and tert-butyl acrylate (9.60 mL; 66.1 mmol) in CH3CN (100 mL) was heated under reflux overnight. After cooling to RT, the mixture was concentrated and purified by column chromatography (SiO2, Et2O) to afford 3-[2-(4-hydroxy-phenyl)-morpholin-4-yl]-propionic acid tert-butyl ester (5.22 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227960B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-fef93bf0d1104a338e33bbc51ec2206d |
| Source note | uspto-grants-2016_01 |