HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-[2-(4-Phenoxy-phenyl)-morpholin-4-yl]-propionic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 3-[2-(4-Phenoxy-phenyl)-morpholin-4-yl]-propionic acid tert-butyl ester | HCID 66653970 | — |
| Product | 3-[2-(4-Phenoxy-phenyl)-morpholin-4-yl]-propionic acid hydrochloride | HCID 66654044 | — |
Reaction Steps
3-[2-(4-Phenoxy-phenyl)-morpholin-4-yl]-propionic acid tert-butyl ester (49 mg) was treated with HCl in 1,4-dioxane (0.5 mL; 4.0 mol/L, 2 mmol) and shaken overnight at room temperature. Removal of the solvent in vacuo yielded 3-[2-(4-phenoxy-phenyl)-morpholin-4-yl]-propionic acid hydrochloride as an amorphous broken white powder (48 mg). Rt=1.60 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227960B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-78676691ab0b45bb94ed4e0b2175f9d9 |
| Source note | uspto-grants-2016_01 |