HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 90418124, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 5-(Chloroacetyl)-1,3-dihydro-2H-indol-2-one | HCID 2060576 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 90418124 | HCID 90418124 | 37% |
Reaction Steps
To a solution of 5-(2-chloroacetyl)indolin-2-one (1.0 g, 4.8 mmol) in DMF (20 ml) was added NaI (0.14 g, 0.96 mmol) and NaN3 (0.37 g, 5.7 mmol), and the mixture was stirred for 2 h at room temperature. H2O and EtOAc were added to the mixture, and the resulting precipitate was filtered and dried to afford 5-(2-azidoacetyl)indolin-2-one (0.38 g, 37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227962B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-d18eba585ce440839563be467d8baa85 |
| Source note | uspto-grants-2016_01 |