Ethyl 5-((3-nitropyridin-2-yl)amino)picolinate → Ethyl 5-((3-aminopyridin-2-yl)amino)picolinate

HRID 588362Notes

Reaction equation

HRID 588362 reaction equation
N1C2C(=NC=CC=2)N(C2C=CC(C(O)=O)=NC=2)N=1.[N+:19]([C:22]1[C:23]([NH:28][C:29]2[CH:30]=[CH:31][C:32]([C:35]([O:37][CH2:38][CH3:39])=[O:36])=[N:33][CH:34]=2)=[N:24][CH:25]=[CH:26][CH:27]=1)([O-])=O>>[NH2:19][C:22]1[C:23]([NH:28][C:29]2[CH:30]=[CH:31][C:32]([C:35]([O:37][CH2:38][CH3:39])=[O:36])=[N:33][CH:34]=2)=[N:24][CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 117652716Ethyl 5-((3-nitropyridin-2-yl)amino)picolinateHCID 1176531005-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)pyridine-2-carboxylic acid

Product 1

HCID 117652883Ethyl 5-((3-aminopyridin-2-yl)amino)picolinate

Procedure

Prepared according to General Procedure F starting from the compound from Step 2 ethyl 5-((3-nitropyridin-2-yl)amino)picolinate (9.30 g, 32.3 mmol) to afford the title compound as a yellow solid (quantitative yield).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-88882270b69d49ffb0146e078e615da9
Source dataset
uspto-grants-2016_01
Patent number
US09227956B2

Reaction notes

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