反应详情

温度

50 °C

To a mixture of the compound form Step 1 ethyl 4-(pyrazolo[1,5-a]pyrimidin-3-yl)benzoate (64 g, 0.24 mol) in MeOH (1 L) was added an aqueous solution of sodium hydroxide (600 mL, 1.2 mol, 2 M). The mixture was heated at 50° C. for 3 h. The mixture was then concentrated to remove the volatiles. The resulting suspension was diluted with water, and aqueous HCl (1 N) was added dropwise until pH 4. The acidified suspension was filtered, and the solids were collected and dried to give the title compound (57 g, 99%) as a yellow solid.

1. concentrationThe mixture was then concentrated
2. customto remove the volatiles
3. additionThe resulting suspension was diluted with water, and aqueous HCl (1 N)
4. additionwas added dropwise until pH 4
5. filtrationThe acidified suspension was filtered
6. customthe solids were collected
7. customdried