ethyl 1-[5-(4-iodo-1-methyl-1H-pyrazol-5-yl)-2H-tetrazol-2-yl]ethyl carbonate → (S)-ethyl 1-[5-(4-iodo-1-methyl-1H-pyrazol-5-yl)-2H-tetrazol-2-yl]ethyl carbonate

Participants

Reaction Steps

407.5 g of Preparation 23, ethyl 1-[5-(4-iodo-1-methyl-1H-pyrazol-5-yl)-2H-tetrazol-2-yl]ethyl carbonate was processed according to Chiral Preparative Chromatography Method 3, followed by concentration of each enantiomer to dryness in vacuo to give isomer 23a (177.4 g, 99.22%, 99.79% e.e.; tR=2.12 min) and isomer 23b (177.74 g, 98.83%, 98.46% e.e; tR=2.59 min).

Provenance & Evidence