HRID588389

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCC[C@@H](Nc2ncccc2Cl)C1

HCID117652951

1-Piperidinecarboxylic acid, 3-[(3-chloro-2-pyridinyl)amino]-, 1,1-dimethylethyl ester, (3R)-

C15H22ClN3O2

HCID117653100

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC[C@@H](N(C(=O)c2ccc(-n3nnc4cccnc43)cn2)c2ncccc2Cl)C1

HCID118898600

未命名化合物

收率 52%

PROCEDURE

实验过程

Prepared using General Procedures A and C starting from Preparation 1 tert-butyl (3R)-3-[(3-chloropyridin-2-yl)amino]piperidine-1-carboxylate (3.22 g, 10.3 mmol) and Preparation 7 5-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)pyridine-2-carboxylic acid (2.37 g, 9.83 mmol) to provide 2.72 g (52%) of the product isolated as a solid.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-078368856e5e4ccaad2c68185d841fe7
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09227956B2
来源说明: uspto-grants-2016_01

反应 SMILES

[Cl:1][C:2]1[C:3]([NH:8][C@@H:9]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[N:22]1[C:30]2[C:25](=[N:26][CH:27]=[CH:28][CH:29]=2)[N:24]([C:31]2[CH:32]=[CH:33][C:34]([C:37](O)=[O:38])=[N:35][CH:36]=2)[N:23]=1>>[Cl:1][C:2]1[C:3]([N:8]([C:37]([C:34]2[CH:33]=[CH:32][C:31]([N:24]3[C:25]4=[N:26][CH:27]=[CH:28][CH:29]=[C:30]4[N:22]=[N:23]3)=[CH:36][N:35]=2)=[O:38])[C@@H:9]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]2)=[N:4][CH:5]=[CH:6][CH:7]=1